Antigen processing and presentation in HIV infection. (September 2019)

• Record Type: Journal Article
• Authors: Boucau, Julie; Le Gall, Sylvie
• Is Part Of: Molecular immunology. Volume 113(2019:Sep.)
• Page Start: 67
• Page End: 74
• Publication Date: 2019-09
• Subjects: HIV -- Immunopeptidome -- Protein degradation -- Immune escape -- T cells -- Vaccine immunogen design; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2018.03.027
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: HIV antigen processing varies across cell subsets relevant to HIV infection or vaccination. HIV has adapted to the antigen processing machinery at the population to limit its presentation to immune cells. Sequence signatures of immune escape or of degradation patterns of antigens may help predict peptides presentable by various MHC complexes. Recent studies on HIV MHC–peptidome identified peptides of unconventional lengths and novel targets for immune recognition. Computational tools to predict HIV epitope processing and presentation and its variability will help design better vaccine immunogens. Abstract: The presentation of virus-derived peptides by MHC molecules constitutes the earliest signals for immune recognition by T cells. In HIV infection, immune responses elicited during infection do not enable to clear infection and correlates of immune protection are not well defined. Here we review features of antigen processing and presentation specific to HIV, analyze how HIV has adapted to the antigen processing machinery and discuss how advances in biochemical and computational protein degradation analyses and in immunopeptidome definition may help identify targets for efficient immune clearance and vaccine immunogen design.