A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). (October 2019)

• Record Type: Journal Article
• Authors: Rades, Dirk; Narvaez, Carlos A.; Splettstößer, Laura; Dömer, Claudia; Setter, Cornelia; Idel, Christian; Ribbat-Idel, Julika; Perner, Sven; Bartscht, Tobias; Olbrich, Denise; Schild, Steven E.; Carl, Jesper
• Is Part Of: Radiotherapy and oncology. Volume 139(2019)
• Page Start: 79
• Page End: 82
• Publication Date: 2019-10
• Subjects: Head-and-neck cancer -- Radiation dermatitis -- Randomized trial -- Mepitel® Film -- Standard care; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2019.07.023
• Languages: English
• ISSNs: 0167-8140

Abstract

Abstract: Mepitel® Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ≥2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50 Gy, 65.2% vs. 59.3% at 60 Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).