A31 GLOBAL BURDEN OF HOSPITALIZATION FOR PERSONS WITH IBD IN THE 21ST CENTURY: TIME TREND ANALYSES. (15th March 2019)

• Record Type: Journal Article
• Authors: Windsor, J W; Buie, M; Coward, S; King, J A; Underwood, F; Quan, J; Panaccione, R; Seow, C; Kaplan, G G
• Is Part Of: Journal of the Canadian Association of Gastroenterology. Volume 2(2019)Supplement 2
• Page Start: 61
• Page End: 63
• Publication Date: 2019-03-15
• Subjects: Gastroenterology -- Periodicals; 616.33005
• DOI: 10.1093/jcag/gwz006.030
• Languages: English
• ISSNs: 2515-2084

Abstract

Abstract: Background: Prevalence of inflammatory bowel disease (IBD) exceeds 0.3% in N. America, Europe, and Oceania, but many Westernized nations report decreasing hospitalization rates (HR) following the advent of biologics. However, IBD incidence is rapidly rising in newly industrialized countries in Asia and S. America, which may correspond to increasing HRs in those regions. Aims: Analyze global time trends of all-cause hospitalizations for persons with IBD. Methods: We conducted a systematic review of MedLine and Embase (2000–2018) to identify population-based studies reporting HRs after the year 2000 with at least five years of data. WorldBank census data were used for population values. Log-linear models were used to analyze time trends and to calculate average annual percentage change (AAPC), with associated 95% confidence intervals (CI). Results: 7, 782 studies were identified; 663 underwent full-text review; data were extracted from 52; and, 17 underwent analysis. HRs were analyzed in 33 countries (Table 1). In N. America, HRs are decreasing in Canada (AAPC:−2.4; 95%CI:−2.6, −2), but increasing in the USA (AAPC:2.4; 95%CI:1.5, 3.3). HRs were also divergent in Europe with countries reporting decreasing (eg. Sweden, AAPC:−2.4; 95%CI:−2.9, −1.8), increasing (eg. Germany, AAPC:2.1; 95%CI:1.8, 2.5), and stable (eg. France, AAPC:−0.1; 95%CI:−0.4, 0.2) rates. In contrast, HRs were rapidly increasing in Asia (eg. China, AAPC:16.4; 95%CI:11.8, 21.2) and S. America (eg. Mexico, AAPC:3.7; 95%CI:2.8, 4.6) (Table 1). Conclusions: Despite advances in IBD management since 2000, HRs are divergent throughout the Western world with over half of countries reporting increases. Newly industrialized countries in Asia and S. America are experiencing rapidly rising HRs, which is contributing to an increasing burden on global healthcare systems. Funding Agencies: CIHR