F52. WHO CO-PARENT CHILDREN WITH MOTHERS AND FATHERS WITH SCHIZOPHRENIA OR BIPOLAR DISORDER? CHARACTERIZING INDIVIDUALS WHO HAVE CHILDREN TOGETHER WITH INDIVIDUALS WITH SCHIZOPHRENIA OR BIPOLAR DISORDER. (9th April 2019)

• Record Type: Journal Article
• Authors: Greve, Aja; Uher, Rudolf; Thorup, Anne; Ellersgaard, Ditte; Christiani, Camilla Jerlang; Spang, Katrine Søborg; Hemager, Nicoline; Møllegaard Jepsen, Jens Richardt; Nordentoft, Merete; Plessen, Kerstin; Bliksted, Vibeke; Mors, Ole
• Is Part Of: Schizophrenia bulletin. Volume 45(2019)Supplement 2
• Page Start: S275
• Page End: S275
• Publication Date: 2019-04-09
• Subjects: Schizophrenia -- Periodicals; Schizophrenia -- Research -- Periodicals; 616.898005
• DOI: 10.1093/schbul/sbz018.464
• Languages: English
• ISSNs: 0586-7614

Abstract

Abstract: Background: Prior studies have established that partners are similar to each other in many aspects. They correlate positively and strongly on age, social attitudes, and religiosity; correlate moderately on general intelligence, education, and physical attractiveness; and correlate weakly on height, weight, and personality traits. It remains unknown if and how this affects partners of individuals with schizophrenia or bipolar disorder. This aspect is clinically relevant when we want to characterize the risk factors for children growing up in families where one parent is living with schizophrenia or bipolar disorder. Therefore, the objective of this study is to investigate the diagnoses of a mental illness, cognitive ability, social functioning and polygenic risk in individuals who have children together with individuals with schizophrenia or bipolar disorder compared to controls. Methods: The Danish High Risk and Resilience Study - VIA7 is a nationwide cohort study conducted in Denmark between January 1, 2013 and January 31, 2016. The VIA7 cohort consists of 522 children aged 7 years with 0, 1 or 2 parents diagnosed with schizophrenia or bipolar disorder and both of their biological parents. Subjects were identified through the Danish Civil registration System and the Danish Psychiatric Central Research register. This study will focus on the biological co-parents (N = 443) without schizophrenia or bipolar disorder in the Danish registries. All participants were interviewed with SCAN and social functioning was measured using PSP. Further, we assessed intelligence (RIST), verbal working memory (Letter-Number Sequencing - WAIS-IV), and processing speed (Coding - WAIS-IV). Results: Data analysis is on-going and data will be presented at the conference. Discussion: Data analysis is on-going and data will be presented at the conference.