0488 Poor Sleep and Daytime Sleepiness Increase the Risk of Hypertension Associated with Mild-to-Moderate Obstructive Sleep Apnea: Age Effect. (12th April 2019)

• Record Type: Journal Article
• Authors: Puzino, Kristina; Vgontzas, Alexandros N; Fernandez-Mendoza, Julio; Krishnamurthy, Venkatesh Basappa; Danisi, Jacqueline M; Basta, Maria; Criley, Carrie; Bixler, Edward O
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A195
• Page End: A196
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.486
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Mild-to-moderate obstructive sleep apnea (OSA) affects 15-40% of the adult general population. However, it remains unclear when and how best to treat mild-to-moderate OSA. It has been shown that mild-to-moderate OSA in general random samples are associated with incident hypertension, particularly in the young and middle aged. In this study we examine whether symptoms modify the association between OSA and hypertension in patients with mild-to-moderate OSA. Methods: A clinical sample of 188 adults (50.06±14.65 years) with mild-to-moderate OSA (AHI between 5 and 29 events per hour) underwent 8-hour polysomnography, a clinical history and physical examination, including measures of blood pressure and body mass index (BMI). Poor sleep was measured with the Pittsburgh Sleep Quality Index (PSQI) and daytime sleepiness was measured with the Epworth Sleepiness Scale (ESS). Hypertension was defined by physician diagnosis, past or present treatment, or blood pressure ≥140/90. All analyses were conducted controlling for gender and BMI. Results: The symptoms of poor sleep and daytime sleepiness were associated with significantly greater odds for hypertension (OR = 2.74, 95% CI = 1.13-6.61, p = 0.025). The association of these symptoms was stronger in those patients younger than 60 (OR = 4.05, 95% CI = 1.35-12.1, p = 0.012), while the association lost significance in those patients above 60 years old (OR = 1.04, 95% CI = 0.20-5.5, p = 0.96). Conclusion: Our data suggest that poor sleep and daytime sleepiness improves the ability for clinicians to detect cases of mild-to-moderate OSA with increased cardiovascular risk. Importantly, the utility of these symptoms is strongest in young and middle aged adults. These results also suggest a different phenotype in older adults with mild-to-moderate OSA compared to young and middle aged adults. Support (If Any): NA