0646 Abnormal Event-related Electroencephalograms In Patients With Rapid-eye Movement (REM) Sleep Behavior Disorder (RBD) During Involuntary Visuospatial Attention Task: A Possible Progression Marker In Neurodegenerative Disease. (12th April 2019)

• Record Type: Journal Article
• Authors: Cha, Kwang Su; Chang, Hye-Yeon; Shin, Yong-Won; Kim, Hyun Woo; Jung, Ki-Young
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A258
• Page End: A258
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.644
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder characterized by dream enactment behavior and the loss of muscle atonia during REM sleep. Recent studies have investigated the predictive marker of the neurodegenerative diseases in RBD including imaging, genetic, neurophysiological, and autonomic function. A variety of cognitive deficits have been revealed in RBD, but there have little evidence as a progression marker of neurodegenerative disease. Our study identified the electrophysiological progression marker of the neurodegenerative disease in RBD from event-related electroencephalogram (ERP) during a visuospatial attention task. Methods: Eighteen idiopathic RBD patients participated in the study. Patients were performed the Posner's cueing paradigm during the 60-channel electroencephalogram (EEG) recording. After the task performed, we investigated whether the patients progressed to Parkinson`s disease (PD) or dementia with Lewy body (DLB). As a result of long-term follow-up, two subjects were converted to PD and 2 subject were converted to DLB. Conventional ERP analysis was performed to identify electrophysiological changes with conversion types. Results: In the 200 ms stimulus onset asynchrony (SOA), RBD without conversion to dementia showed the significantly increased N1 ERP component in valid than invalid condition. However, RBD who converted to dementia showed no significant difference of N1 ERP component between valid and invalid condition. In the 1000 ms SOA, no significant differences of N1 ERP component between valid and invalid were observed regardless of whether the conversion being proceeded. Conclusion: Abnormal N1 ERP component in the long SOA may reflect the deficit in oculomotor and attentional inhibitory control in RBD patients regardless of conversion to dementia. Abnormal N1 ERP component in the short SOA, which was only observed in RBD who converted to dementia, revealed that facilitation deficit may be considered as a clinical feature of dementia conversion. Our findings suggested that visuospatial attention deficit in RBD may be as a part of prodromal markers of neurodegenerative disease. Support (If Any): National Research Foundation of Korea (NRF) (2017R1A2B2012280, 2017M3C7A1029485).