0902 Nocturnal Heart Rate Variability Moderates the Association Between Sleep-Wake Regularity and Mood in Young Adults. (12th April 2019)

• Record Type: Journal Article
• Authors: Gao, Lei; Li, Peng; Hu, Chelsea; Wong, Patricia; Lin, Chen; Lo, Men-Tzung; Scheer, Frank; Hu, Kun
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A362
• Page End: A363
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.900
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Sleep-wake regularity (SWR) is often disrupted in early adult life. Repetitive and long-term misalignment between environmental and behavioral cycles may have subsequent psychological and physical health consequences, including autonomic function. We tested whether SWR was independently associated with mood and autonomic function in a healthy adult cohort. We also explored the relationship between other potential contributors to circadian misalignment (social jetlag, chronotype, and delayed-bedtime) on SWR, mood and autonomic function. Methods: We studied 42 college students over a 3-week period using daily sleep-wake, and physical activity diaries, as well as continuous electrocardiogram via a Holter monitor (DF-010, DELBio, INC.) SWR was quantified for each week by calculating the interdaily stability of sleep-wake timing (ISSW ) across 24h periods. Mood was assessed weekly using the Beck Depression Inventory-II (BDI). To assess autonomic function, we quantified the high frequency power (HF) of heart rate variability (HRV). Linear mixed effects models were used to account for repeated weekly measures. Results: Low weekly ISSW predicted subsequent poor mood and worsening mood independently of age, sex, race, sleep duration, and physical activity (b = -0.16, 95% CI -0.24 to -0.08, p = 0.0003). While no association was found between ISSW and HF (p > 0.05), the SWR-mood association was significantly moderated by nocturnal HF (b = -0.27, 95% CI -0.45 to -0.09, p = 0.005) i.e. mood was poorest after a week with low ISSW and high nocturnal HF. These relationships remained significant after accounting for social jetlag, chronotype, and delayed-bedtime. Prior week mood scores had no bearing on the subsequent week's ISSW (p > 0.05). Conclusion: Irregular weekly sleep-wake timing appears to precede poor mood in young adults. Further work is needed to understand the implications of high nocturnal HRV in those with low mood and irregular sleep-wake cycles. Support (If Any): This work was supported by NIH grants T32GM007592, R01AG048108, and RF1AG059867.