Maternal Measles Antibodies and Their Influence on All-cause Mortality Following Measles Vaccination: An Alternative to Measure Very Low Maternal Antibody Levels. (16th October 2018)

• Record Type: Journal Article
• Authors: Smits, Gaby; Stabell Benn, Christine; Whittle, Hilton; van Binnendijk, Rob; Aaby, Peter; van der Klis, Fiona
• Is Part Of: Clinical infectious diseases. Volume 68:Number 10(2019)
• Page Start: 1758
• Page End: 1760
• Publication Date: 2018-10-16
• Subjects: maternal measles antibodies -- all-cause mortality -- HAI -- multiplex immunoassay; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciy900
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower all-cause mortality ( P = .02).