Antiretroviral Concentrations in Hair Strongly Predict Virologic Response in a Large Human Immunodeficiency Virus Treatment-naive Clinical Trial. (3rd September 2018)

• Record Type: Journal Article
• Authors: Gandhi, Monica; Bacchetti, Peter; Ofokotun, Igho; Jin, Chengshi; Ribaudo, Heather J; Haas, David W; Sheth, Anandi N; Horng, Howard; Phung, Nhi; Kuncze, Karen; Okochi, Hideaki; Landovitz, Raphael J; Lennox, Jeffrey; Currier, Judith S
• Is Part Of: Clinical infectious diseases. Volume 68:Number 6(2019)
• Page Start: 1044
• Page End: 1047
• Publication Date: 2018-09-03
• Subjects: HIV -- A5257 study -- AIDS Clinical Trials Group (ACTG) -- hair concentrations -- non-NNRTI regimens; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciy764
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Concentrations of antiretrovirals in hair are associated with virologic outcomes in cohorts of human immunodeficiency virus (HIV)-positive individuals but have never been examined in a clinical trial. We show for the first time the predictive utility of hair antiretroviral concentrations in a large HIV treatment-naive trial (AIDS Clinical Trials Group protocol A5257).