In vivo role of capsular polysaccharide in Mycoplasma mycoides. (12th December 2018)

• Record Type: Journal Article
• Authors: Jores, Joerg; Schieck, Elise; Liljander, Anne; Sacchini, Flavio; Posthaus, Horst; Lartigue, Carole; Blanchard, Alain; Labroussaa, Fabien; Vashee, Sanjay
• Is Part Of: Journal of infectious diseases. Volume 219:Number 10(2019)
• Page Start: 1559
• Page End: 1563
• Publication Date: 2018-12-12
• Subjects: Mycoplasma mycoides -- M. mycoides subsp. capri -- carbohydrate -- glycan -- galactofuranose -- virulence factor -- vaccine -- CPS; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiy713
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract : Many Mycoplasma species have been shown to possess capsular polysaccharides (CPSs). We challenged goats with a CPS-defective or its CPS-possessing parental Mycoplasma mycoides strain. The CPS-defective strain was attenuated, demonstrating that the CPS consisting of galactofuranose is a virulence trait. Abstract: Capsular polysaccharides have been confirmed to be an important virulence trait in many gram-positive and gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In the current study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. capri or an engineered mutant lacking the capsular polysaccharide, galactofuranose. Goats infected with the mutant strain showed only transient fever. In contrast, 5 of 8 goats infected with the parental strain reached end-point criteria after infection. These findings confirm that galactofuranose is a virulence factor in M. mycoides .