Synaptic Potentiation at Basal and Apical Dendrites of Hippocampal Pyramidal Neurons Involves Activation of a Distinct Set of Extracellular and Intracellular Molecular Cues. (8th December 2017)

• Record Type: Journal Article
• Authors: Brzdak, Patrycja; Wójcicka, Olga; Zareba-Koziol, Monika; Minge, Daniel; Henneberger, Christian; Wlodarczyk, Jakub; Mozrzymas, Jerzy W; Wójtowicz, Tomasz
• Is Part Of: Cerebral cortex. Volume 29:Number 1(2019)
• Page Start: 283
• Page End: 304
• Publication Date: 2017-12-08
• Subjects: dopamine receptor -- matrix metalloproteases -- NMDA receptor -- protease activated receptor -- synaptic plasticity; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bhx324
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract: In the central nervous system, several forms of experience-dependent plasticity, learning and memory require the activity-dependent control of synaptic efficacy. Despite substantial progress in describing synaptic plasticity, mechanisms related to heterogeneity of synaptic functions at local circuits remain elusive. Here we studied the functional and molecular aspects of hippocampal circuit plasticity by analyzing excitatory synapses at basal and apical dendrites of mouse hippocampal pyramidal cells (CA1 region) in acute brain slices. In the past decade, activity of metalloproteinases (MMPs) has been implicated as a widespread and critical factor in plasticity mechanisms at various projections in the CNS. However, in the present study we discovered that in striking contrast to apical dendrites, synapses located within basal dendrites undergo MMP-independent synaptic potentiation. We demonstrate that synapse-specific molecular pathway allowing MMPs to rapidly upregulate function of NMDARs in stratum radiatum involved protease activated receptor 1 and intracellular kinases and GTPases activity. In contrast, MMP-independent scaling of synaptic strength in stratum oriens involved dopamine D1/D5 receptors and Src kinases. Results of this study reveal that 2 neighboring synaptic systems differ significantly in extracellular and intracellular cascades that control synaptic gain and provide long-searched transduction pathways relevant for MMP-dependent synaptic plasticity.