Highly convergent modular access to poly-carbon substituted cyclopropanes via Cu(i)-catalyzed three-component cyclopropene carboallylation. Issue 19 (28th August 2019)

• Record Type: Journal Article
• Authors: Li, Hexin; Zhang, Mengru; Mehfooz, Haroon; Zhu, Dongxia; Zhao, Jinbo; Zhang, Qian
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 19(2019)
• Page Start: 3387
• Page End: 3391
• Publication Date: 2019-08-28
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00902g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : The first conjunctive C–C cross-coupling of cyclopropenes is realized by a Cu-catalyzed three-component reaction with an organoboron reagent and allylic electrophiles, featuring a modular, stereoselective assembly of poly-carbon substituted cyclopropanes. Abstract : We report herein the first example of conjunctive C–C cross-coupling of cyclopropenes enabled by a Cu-catalyzed three-component reaction of organoboron, cyclopropene and allylic bromide, which features a modular, stereoselective assembly of poly-carbon substituted cyclopropanes. Preliminary studies showed that the reaction can be extended to benzylation and made enantioselective with C 2 -symmetrical bisphosphine ligands.