The regulatory network behind MHC class I expression. (September 2019)

• Record Type: Journal Article
• Authors: Jongsma, Marlieke L.M.; Guarda, Greta; Spaapen, Robbert M.
• Is Part Of: Molecular immunology. Volume 113(2019:Sep.)
• Page Start: 16
• Page End: 21
• Publication Date: 2019-09
• Subjects: MHC class I -- NLRC5 -- Transcription -- Expression -- Regulation -- Screen; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2017.12.005
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: The NLR family member NLRC5 is a regulator of MHC class I transcription. The knowledge on the mechanisms behind basal MHC class I transcription is very limited. Genome-wide and other high-end screening approaches will uncover the unknowns of MHC class I transcription in the near future. Abstract: The MHC class I pathway, presenting endogenously derived peptides to T lymphocytes, is hijacked in many pathological conditions. This affects MHC class I levels and peptide presentation at the cell surface leading to immune escape of cancer cells or microbes. It is therefore important to identify the molecular mechanisms behind MHC class I expression, processing and antigen presentation. The identification of NLRC5 as regulator of MHC class I transcription was a huge step forward in understanding the transcriptional mechanism involved. Nevertheless, many questions concerning MHC class I transcription are yet unsolved. Here we illuminate current knowledge on MHC class I and NLRC5 transcription, we highlight some remaining questions and discuss the use of quickly developing high-content screening tools to reveal unknowns in MHC class I transcription in the near future.