Multiscale dynamics of branching morphogenesis. (October 2019)

• Record Type: Journal Article
• Authors: Hannezo, Edouard; Simons, Benjamin D
• Is Part Of: Current opinion in cell biology. Volume 60(2019)
• Page Start: 99
• Page End: 105
• Publication Date: 2019-10
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2019.04.008
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract : Branching morphogenesis is a prototypical example of complex three-dimensional organ sculpting, required in multiple developmental settings to maximize the area of exchange surfaces. It requires, in particular, the coordinated growth of different cell types together with complex patterning to lead to robust macroscopic outputs. In recent years, novel multiscale quantitative biology approaches, together with biophysical modelling, have begun to shed new light of this topic. Here, we wish to review some of these recent developments, highlighting the generic design principles that can be abstracted across different branched organs, as well as the implications for the broader fields of stem cell, developmental and systems biology.