A simple synthesis of ketone from carboxylic acid using tosyl chloride as an activator. Issue 39 (26th September 2019) - Sahoo, Debasis
Graphical abstract: Highlights: Simple and effective method. TsCl is used as an activator of carboxylic acid. Mild reaction conditions. Aromatic, aliphatic acids react smoothly. Abstract: An effective process for the conversion of carboxylic acid to ketone has been discovered. In this process, carboxylic acid has been activated using p -toluene sulphonyl group. Under the optimized condition, aromatic, aliphatic heteroaromatic carboxylic acids have been proved to be good substrates for this methodology. The byproduct of this reaction can be removed very easily during work up process. Also, one equivalent of organometallic reagent is sufficient to complete this transformation.