Transgene and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus. (1st January 2017)

• Record Type: Journal Article
• Authors: Ito, Kiyonori; Ookawara, Susumu; Ishibashi, Kenichi; Morishita, Yoshiyuki
• Is Part Of: Nano reviews & experiments. Volume 8(2017)
• Publication Date: 2017-01-01
• Subjects: Diabetes mellitus -- gene therapy -- allogenic pancreatic islet cell transplantation -- delivery system -- viral vector -- non-viral vector; Nanoscience -- Periodicals; Nanotechnology -- Periodicals; Nanobiotechnology -- Periodicals; Nanobiotechnology; Nanoscience; Nanotechnology; Nanotechnology; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; 620.5
• DOI: 10.1080/20022727.2017.1341758
• Languages: English
• ISSNs: 2002-2727

Abstract

ABSTRACT: Gene therapy that targets the pancreas and intestines with delivery systems using nano-sized carriers such as viral and non-viral vectors could improve the control of blood glucose levels, resulting in an improved prognosis for patients with diabetes mellitus. Allogenic pancreatic islet cell transplantations using such delivery systems have been developed as therapeutic options for diabetes mellitus. This review focuses on transgenes and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus.