Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations. (22nd November 2018)

• Record Type: Journal Article
• Authors: Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Edwards, Andrew G; Fyhn, Marianne; Djurovic, Srdjan; Dale, Anders M; Andreassen, Ole A; Einevoll, Gaute T
• Is Part Of: Cerebral cortex. Volume 29:Number 2(2019)
• Page Start: 875
• Page End: 891
• Publication Date: 2018-11-22
• Subjects: forward modeling of EEG -- functional genomics -- ion channels -- multicompartmental neuron modeling -- schizophrenia genetics; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bhy291
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract: Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of common variation in these channels to neurophysiological biomarkers and symptoms of schizophrenia remain elusive. Here, using computational modeling, we show that a common biomarker of schizophrenia, namely, an increase in delta-oscillation power, may be a direct consequence of altered expression or kinetics of voltage-gated ion channels or calcium transporters. Our model of a circuit of layer V pyramidal cells highlights multiple types of schizophrenia-related variants that contribute to altered dynamics in the delta-frequency band. Moreover, our model predicts that the same membrane mechanisms that increase the layer V pyramidal cell network gain and response to delta-frequency oscillations may also cause a deficit in a single-cell correlate of the prepulse inhibition, which is a behavioral biomarker highly associated with schizophrenia.