Frontispiece: A Novel Cathode Material for Cathodic Dehalogenation of 1, 1‐Dibromo Cyclopropane Derivatives. Issue 40 (16th September 2015)

• Record Type: Journal Article
• Authors: Gütz, Christoph; Selt, Maximilian; Bänziger, Markus; Bucher, Christoph; Römelt, Christina; Hecken, Nadine; Gallou, Fabrice; Galvão, Tomás R.; Waldvogel, Siegfried R.
• Is Part Of: Chemistry. Volume 21:Issue 40(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-09-16
• Subjects: cyclopropanes -- dehalogenation -- electrochemical reduction -- leaded bronze -- sustainable chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201584061
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Pharmaceutical Electrochemistry . The electrochemical dehalogenation represents a powerful and sustainable tool for the synthesis of pharmaceutically relevant cyclopropane building blocks in excellent yield. The key to the conversion is the leaded bronze cathode instead of traditional lead. This novel cathode material is less prone to corrosion and provides highly pure product. Thereby, contamination by heavy metal traces is tremendously reduced. Furthermore, by slightly switching the electrolysis conditions, selective mono‐ or twofold dehalogenation is achieved. For more details, see the Communication by S. R. Waldvogel and co‐workers onpage 13878 ff.