Electroanalytic Aspects of Single‐Entity Collision Methods for Bioanalytical and Environmental Applications. Issue 20 (18th July 2018)

• Record Type: Journal Article
• Authors: Andreescu, Daniel; Kirk, Kevin A.; Narouei, Farideh Hosseini; Andreescu, Silvana
• Is Part Of: ChemElectroChem. Volume 5:Issue 20(2018)
• Page Start: 2920
• Page End: 2936
• Publication Date: 2018-07-18
• Subjects: collision electrochemistry -- bioanalysis -- nanoimpact -- nanoparticles -- environmental chemistry; Electrochemistry -- Periodicals; 541.37
• DOI: 10.1002/celc.201800722
• Languages: English
• ISSNs: 2196-0216

Abstract

Abstract: Single‐entity electrochemistry based on measurements of collision events at electrode surfaces is a rapidly developing field which provides extensive capabilities for detection and characterization of a variety of materials including organic and inorganic nanoparticles (NPs) and nanostructures as well as biologicals. The method has demonstrated promising potential for the analysis of catalytic activity, physicochemical parameters, fundamental surface properties, functionalization and reactivity of NPs. Here, the most recent developments and capabilities of this method as a novel tool for characterizing nanoscale properties are discussed, illustrating novel applications for assessing bioconjugation, designing ultrasensitive biosensing methods and monitoring processes of biological and environmental significance. The main advantages and limitations as compared to commonly used spectroscopy and imaging techniques are described, highlighting areas in which collision measurements can be used as a complementary approach to characterize properties of inorganic NPs, organic molecules, soft materials and biologicals, and develop methodologies for detection and quantification of analytes of interest in the bioanalytical, biological and environmental fields. An overview of potential applications in these fields is provided along with a critical discussion of future research needs and opportunities. Abstract : Crash course on collision events : Single‐entity electrochemistry based on measurements of collision events at electrode surfaces can be utilized to study a variety of fundamental nanomaterial properties such as surface modification, dissolution, reactivity, conformational changes of ligands and electron transfer. The method can be applied to inorganic, organic or soft materials as well as biological molecules like DNA, liposomes, viruses and bacteria.