Antimicrobial efficiency of diorganotin(IV) bis-[3-(4-chlorophenyl)-2-methylacrylate]. Issue 20 (18th October 2018) - Muhammad, Niaz
Abstract: Four new diorganotin(IV) carboxylates, [ n -Bu2 SnL2 ] (1 ), [Et2 SnL2 ] (2 ), [Me2 SnL2 ] (3 ) and [ n -Oct2 SnL2 ] (4 ), where L = 3-(4-chlorophenyl)-2-methylacrylate, were synthesized and characterized by elemental analysis, FT-IR, multinuclear NMR ( 1 H, 13 C, and 119 Sn) and X-ray single crystal analysis for1 . A chelating bidentate ligand and six-coordinate tin centers were confirmed in the solid state by IR for all complexes and for1 by X-ray single crystal analysis. The NMR study has shown a decrease in the coordination number of tin in solution. The complexes were screened for their in vitro antibacterial and antifungal activities. A compromised lipo/hydrophilicity and a diffusion controlled antimicrobial activity was shown by the complexes in the order1 > 2 >3 > 4 . Molecular docking studies have shown hydrogen bonding and hydrophobic interactions for1 with the target proteins of the antimicrobial strains. Graphical Abstract: