Key interindividual determinants in MDMA pharmacodynamics. (1st February 2018)

• Record Type: Journal Article
• Authors: Papaseit, E.; Torrens, M.; Pérez-Mañá, C.; Muga, R.; Farré, M.
• Is Part Of: Expert opinion on drug metabolism and toxicology. Volume 14:Number 2(2018)
• Page Start: 183
• Page End: 195
• Publication Date: 2018-02-01
• Subjects: MDMA -- 3, 4-methylenedioxymethamphetamine -- pharmacodynamics -- pharmacokinetics -- sex-gender -- race-ethnicity -- genetic polymorphisms; Drugs -- Toxicology -- Periodicals; Drugs -- Metabolism -- Periodicals; 615.7
• DOI: 10.1080/17425255.2018.1424832
• Languages: English
• ISSNs: 1742-5255

Abstract

ABSTRACT: Introduction : MDMA, 3, 4-methylenedioxymethamphetamine, is a synthetic phenethylamine derivative with structural and pharmacological similarities to both amphetamines and mescaline. MDMA produces characteristic amphetamine-like actions (euphoria, well-being), increases empathy, and induces pro-social effects that seem to motivate its recreational consumption and provide a basis for its potential therapeutic use. Areas covered : The aim of this review is to present the main interindividual determinants in MDMA pharmacodynamics. The principal sources of pharmacodynamic variability are reviewed, with special emphasis on sex-gender, race-ethnicity, genetic differences, interactions, and MDMA acute toxicity, as well as possible therapeutic use. Expert opinion : Acute MDMA effects are more pronounced in women than they are in men. Very limited data on the relationship between race-ethnicity and MDMA effects are available. MDMA metabolism includes some polymorphic enzymes that can slightly modify plasma concentrations and effects. Although a considerable number of studies exist about the acute effects of MDMA, the small number of subjects in each trial limits evaluation of the different interindividual factors and does not permit a clear conclusion about their influence. These issues should be considered when studying possible MDMA therapeutic use.