Exercise training reduces oxidative stress in people living with HIV/AIDS: a pilot study. Issue 4 (4th July 2018)

• Record Type: Journal Article
• Authors: Deresz, Luís Fernando; Schöler, Cinthia Maria; de Bittencourt, Paulo Ivo Homem Júnior; Karsten, Marlus; Ikeda, Maria Letícia Rodrigues; Sonza, Anelise; Dal Lago, Pedro
• Is Part Of: HIV clinical trials. Volume 19:Issue 4(2018)
• Page Start: 152
• Page End: 157
• Publication Date: 2018-07-04
• Subjects: AIDS -- aerobic exercise -- strength training -- antiretroviral therapy -- oxidative stress; HIV Infections -- Chemotherapy -- Periodicals; AIDS (Disease) -- Chemotherapy -- Periodicals; HIV Infections -- Research -- Periodicals; AIDS (Disease) -- Research -- Periodicals; 616.979206105
• DOI: 10.1080/15284336.2018.1481247
• Languages: English
• ISSNs: 1528-4336

Abstract

Abstract : Background: Exercise training has been shown to be an effective strategy to balance oxidative stress status; however, this is underexplored in people living with HIV/AIDS (PLWHA). Objective: To evaluate the effects of exercise training on oxidative stress in PLWHA receiving antiretroviral therapy. Methods: Patients performed 24 sessions (3 times per week, 8 weeks) of either aerobic (AT), resistance (RT), or concurrent training (CT). Glutathione disulphide to glutathione ratio (GSSG/GSH) in circulating erythrocytes and thiobarbituric acid–reactive substances (TBARS) in plasma samples were assessed as oxidative stress markers. Eight PLWAH completed the training protocol (AT =3, RT =3, CT =2). The GSSG/GSH and TBARS values were logarithmically transformed to approximate a normal distribution. A paired t -test was used to determine the differences between baseline and post-training values. Results: Data-pooled analysis showed a decrease in GSSG/GSH and TBARS after the training period: log GSSG/GSH= –1.26 ± 0.57 versus –1.54 ± 0.65, p = .01 and log TBARS =0.73 ± 0.35 versus 0.43 ± 0.21, p = .01. This was paralleled by a rise in peak oxygen uptake (VO2peak = 29.14 ± 5.34 versus 32.48 ± 5.75 ml kg −1 min −1, p = .04). All the subjects who performed resistance exercises showed an average gain of 37 ± 8% in muscle strength with no difference between performing single or multiple sets in terms of muscle strength gain. The results reinforce the clinical importance of exercise as a rehabilitation intervention for PLWHA and emphasizes the safety of exercise at the physiological level with the potential to mediate health outcomes.