Insights into the intestinal bacterial metabolism of flavonoids and the bioactivities of their microbe-derived ring cleavage metabolites. (3rd July 2018)

• Record Type: Journal Article
• Authors: Feng, Xinchi; Li, Yang; Brobbey Oppong, Mahmood; Qiu, Feng
• Is Part Of: Drug metabolism reviews. Volume 50:Number 3(2018)
• Page Start: 343
• Page End: 356
• Publication Date: 2018-07-03
• Subjects: Flavonoids -- intestinal bacterial metabolism -- microbe-derived metabolites -- phenolic acids -- antioxidant -- anti-inflammatory; Drugs -- Metabolism -- Periodicals; Pharmacokinetics -- Periodicals; Pharmaceutical Preparations -- metabolism -- Periodicals; 615
• DOI: 10.1080/03602532.2018.1485691
• Languages: English
• ISSNs: 0360-2532

Abstract

Abstract: Flavonoids are a group of phytochemicals widely distributed in plants, fruits, and vegetables that possess numerous bioactivities. After oral administration, flavonoids can be metabolized by the intestinal bacteria into a wide range of low-molecular-weight phenolic acids. In this review, the intestinal bacterial metabolic pathways of different flavonoids (flavones, isoflavones, flavonols, flavanones, and chalcones) and the bioactivities of their microbe-derived ring cleavage metabolites are summarized. Flavonoids undergo different intestinal bacterial metabolic reactions, depending on the characteristics of their structure. Free hydroxyl groups, especially 5 and 4' free hydroxyl groups play significant roles in fission metabolism. Microbe-derived ring cleavage metabolites such as 3, 4-dihydroxyphenylacetic acid (3, 4-DHPAA) and 3, 4-dihydroxytoluene (3, 4-DHT) possess various bioactivities including antioxidant, anti-inflammatory, antidiabetic, neuroprotective, and anti-colon cancer effects. Also, the intestinal bacteria associated with the bacterial metabolism of flavonoids are covered in this review.