Hyperferritinemia: causes and significance in a general hospital. Issue 10 (26th November 2018)

• Record Type: Journal Article
• Authors: Senjo, Hajime; Higuchi, Takakazu; Okada, Sadamu; Takahashi, Osamu
• Is Part Of: Hematology. Volume 23:Issue 10(2018)
• Page Start: 817
• Page End: 822
• Publication Date: 2018-11-26
• Subjects: Hyperferritinemia -- ferritin -- etiology -- general practice -- hemophagocytic lymphohistiocytosis; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1080/10245332.2018.1488569
• Languages: English
• ISSNs: 1024-5332

Abstract

ABSTRACT: Objective: To elucidate conditions which cause elevation of the serum ferritin, extent of the elevation in each condition, and clinical relevance of hyperferritinemia in general practice. Methods: We retrospectively studied medical records of all patients who had at least one serum ferritin measurement above 500 μg L −1 . Patients who had a marked elevation of the serum ferritin over 10, 000 μg L −1 were studied separately. Results: We studied 1394 patients to identify the etiologies of hyperferritinemia. Median serum ferritin level was 1024 μg L −1 and 49.2% had ferritin levels of 501–1000 μg L −1 . The most frequent cause of hyperferritinemia was non-human immunodeficiency virus infection followed by solid tumor, liver dysfunction, renal failure, and hematological malignancy. The distributions of the causes were different among groups stratified by the ferritin level. Forty-one percent had multiple causes and there was a tendency that the more underlying causes a patient had, the higher the ferritin level. Each condition led to a wide range of the ferritin level, and some patients could present with marked hyperferritinemia. Seventy percent of 111 patients with marked hyperferritinemia had multiple etiologies and a variety of diseases could lead to marked hyperferritinemia by themselves. Discussion: Patients with hyperferritinemia frequently had multiple conditions. The level of the serum ferritin was determined by the underlying conditions to a certain extent; however, the variation was significant. While patients with marked hyperferritinemia mostly had multiple underlying causes, various diseases could cause hyperferritinemia by themselves. Conclusion: Hyperferritinemia is associated with both etiology and the number of underlying causes.