Guerbet glycolipids from mannose: liquid crystals properties. Issue 13 (8th December 2018)

• Record Type: Journal Article
• Authors: Patrick, Melonney; Zahid, N. Idayu; Kriechbaum, Manfred; Hashim, Rauzah
• Is Part Of: Liquid crystals. Volume 45:Issue 13/15(2018)
• Page Start: 1970
• Page End: 1986
• Publication Date: 2018-12-08
• Subjects: Mannoside -- glycolipids -- liquid crystal -- metastable phase -- thermotropic cubic phase -- non-lamellar phase; Liquid crystals -- Periodicals; 548.905
• DOI: 10.1080/02678292.2018.1492036
• Languages: English
• ISSNs: 0267-8292

Abstract

ABSTRACT: Using mannose as the sugar head, five Guerbet glycolipids with chain ranges from C8 to C24 were synthesised and studied for their liquid crystal behaviour. Differential scanning calorimetry, optical polarising microscopy and small-angle X-ray scattering were employed to determine the thermal, phase and structure properties. Unlike monoalkylated glycolipids, these Guerbet mannosides showed a glass transition below 0°C, except for α-Man-OC14 C10 . In the dry state, lamellar was observed for α-Man-OC6 C2 and α-Man-OC8 C4, while α-Man-OC12 C8 and α-Man-OC14 C10 formed non-lamellar phases, including inverse bicontinuous cubic phase of space group Ia 3 d and inverse hexagonal phase, respectively. The phase for middle-chain mannoside (α-Man-OC10 C6 ) could not be assigned conclusively at room temperature, but this metastable phase forms lamellar above 37°C. The partial binary phase diagrams in water were also determined. Under excess water conditions at room and physiological temperatures, these materials form normal micellar solution, lamellar, inverse bicontinuous cubic of space group Pn 3 m and inverse hexagonal phases. The results were compared with those from other monosaccharide glycolipids from the same sugar Guerbet family. Although these compounds are obvious candidate material for lyotropic applications such as drug carrier and protein crystallisation medium, possible thermotropic application is now being explored. GRAPHICAL ABSTRACT: