Effects of maternal body mass index on pregnancy outcome after 8570 artificial insemination cycles with donor's sperm. (2nd December 2018) - Na, Li
Abstract: Increased body mass index (BMI) might have an adverse effect on pregnancy. However, the influence of BMI on the pregnancy outcomes after artificial insemination with donor's sperm (AID) had been rarely reported. This study aimed to investigate the correlation between BMI and AID. The pregnancy outcome of 8570 AID cycles was retrospectively analyzed. BMI was categorized as underweight (<18.5 kg/m 2 ; group A), normal weight (18.5–23.9 kg/m 2 ; group B), overweight (24–27.9 kg/m 2 ; group C), and obese (≥28 kg/m 2 ; group D). The results showed that cumulative pregnancy rate and cumulative live birth rate in groups A, B, C and D tended to decrease as BMI increased; however, abortion rate, and ectopic pregnancy rate in groups A, B, C, and D exhibited a gradual increase in the tendency. Cesarean delivery rate also increased as BMI increased. Birth defect rate in the group D were significantly higher than that in the group A. Interestingly, the pregnancy rate was gradually decreased with increasing age in groups A, B, and C, but this was not observed in the group D. The findings suggested that BMI can affect the pregnancy outcomes after AID; it is important to achieve a normal BMI prior to AID treatments. 摘要: 体重指数（BMI）的增加对妊娠可能产生不利影响。然而, BMI对供精者精子（AID）人工授精后妊娠结局的影响少有报道。本研究旨在探讨BMI与AID之间的相关性。本研究回顾性分析了8570例AID的妊娠结局。 依据BMI分为低体重组（<18.5 kg / m2；A组）, 正常体重组（18.5-23.9 kg/m 2 ；B组）, 超重组（24-27.9 kg/m 2 ；C组）和肥胖组（≥28kg/m 2 ；D组）。结果表明, 随体重指数的增加, A、B、C、D组中总体妊娠率和总体活产率呈减少趋势；然而, A、B、C和D组的流产率和异位妊娠率呈现逐渐增加的趋势。随着BMI的增加, 剖宫产率也有所增加。 D组的出生缺陷率明显高于A组。有趣的是, A、B、C组中妊娠率随年龄增长逐渐下降, 但在D组中未观察到相同现象。研究结果表明, BMI可以影响AID后的妊娠结局；在AID治疗之前控制BMI在正常范围很重要。