Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients. (17th November 2018)

• Record Type: Journal Article
• Authors: Cichon, Natalia; Bijak, Michal; Synowiec, Ewelina; Miller, Elzbieta; Sliwinski, Tomasz; Saluk-Bijak, Joanna
• Is Part Of: Scandinavian journal of clinical & laboratory investigation. Volume 78:Number 7/8(2018)
• Page Start: 626
• Page End: 631
• Publication Date: 2018-11-17
• Subjects: Extremely low frequency electromagnetic field -- antioxidant enzymes -- stroke -- gene expression -- rehabilitation; Clinical biochemistry -- Periodicals; Physiology, Pathological -- Periodicals; Physiology, Experimental -- Periodicals; Medicine -- Research -- Periodicals; Clinical medicine -- Periodicals; 616.0072
• DOI: 10.1080/00365513.2018.1542540
• Languages: English
• ISSNs: 0036-5513

Abstract

Abstract: Oxidative stress plays the most important role in the pathogenesis of stroke. Extremely low frequency electromagnetic field (ELF-EMF) therapy may be complementary in post-stroke therapy, as it modulates oxidative stress. The aim of this study was to evaluate the messenger ribonucleic acid (mRNA) levels of certain antioxidant genes in post-stroke patients given ELF-EMF therapy. Forty-eight post-stroke patients were divided into two groups: an ELF-EMF group and a non-ELF-EMF group. All patients underwent the same program of physical therapy, but the ELF-EMF group was additionally given ELF-EMF treatment. In order to determine the level of gene expression, we evaluated the level of mRNA expression of catalase, superoxide dismutase, and glutathione peroxidase. We observed that after ELF-EMF therapy, the mRNA expression of the studied genes ( CAT, SOD1, SOD2, GPx1, and GPx4 ) significantly increased, which enhanced the antioxidant defence of the body. ELF-EMF therapy intensifies the endogenous antioxidant system by increasing the mRNA expression of genes encoding antioxidant enzymes and enhances the effectiveness of post-stroke patient therapy.