'Borono-lectin' based engineering as a versatile platform for biomedical applications. Issue 1 (31st December 2018)

• Record Type: Journal Article
• Authors: Matsumoto, Akira; Miyahara, Yuji
• Is Part Of: Science and technology of advanced materials. Volume 19:Issue 1(2018)
• Page Start: 18
• Page End: 30
• Publication Date: 2018-12-31
• Subjects: Boronic acids -- borono-lectins -- drug delivery systems -- sialic acids -- diabetes -- insulin -- siRNA; 30 Bio-inspired and biomedical materials -- 212 Surface and interfaces; Materials -- Technological innovations -- Periodicals; 620.112
• DOI: 10.1080/14686996.2017.1411143
• Languages: English
• ISSNs: 1468-6996

Abstract

Abstract: Boronic acids are well known for their ability to reversibly interact with the diol groups, a common motif of biomolecules including sugars and ribose. Due to their ability to interact with carbohydrates, they can be regarded as synthetic mimics of lectins, termed 'borono-lectins'. The borono-lectins can be tailored to elicit a broad profile of binding strength and specificity. This special property has been translated into many creative biomedical applications in a way interactive with biology. This review provides a brief overview of recent efforts of polymeric materials-based engineering taking advantage of such virtue of 'borono-lectins' chemistry, related to the field of biomaterials and drug delivery applications. Abstract :