Highly efficient cascading synergy of cancer photo-immunotherapy enabled by engineered graphene quantum dots/photosensitizer/CpG oligonucleotides hybrid nanotheranostics. (June 2019)

• Record Type: Journal Article
• Authors: Wu, Chunhui; Guan, Xiaotian; Xu, Jiming; Zhang, Yingxue; Liu, Qiuyue; Tian, Yuan; Li, Shun; Qin, Xiang; Yang, Hong; Liu, Yiyao
• Is Part Of: Biomaterials. Volume 205(2019)
• Page Start: 106
• Page End: 119
• Publication Date: 2019-06
• Subjects: Graphene quantum dots -- Immunoadjuvant -- PhotoImmunoNanotherapy -- Dual-modal imaging; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2019.03.020
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Currently, photoimmunotherapy based on a theranostic nanoplatform emerges as a promising modality in advanced cancer therapy. In this study, a new type of versatile nanoassemblies (denoted asPC@GCpD(Gd) ) was rationally designed by integrating the polydopamine stabilized graphene quantum dots (GQD)-photosensitizer nanocomposites (denoted as GCpD), immunostimulatory polycationic polymer/CpG oligodeoxynucleotide (CpG ODN) nanoparticles (denoted as PC) and Gd 3+ /Cy3 imaging probes for dual magnetic resonance/fluorescence imaging-guided photoimmunotherapy.PC@GCpD(Gd) effectively killed the tumor cells through the amplified photothermal and photodynamic effects mediated by GCpD, and contemporaneously delivered CpG ODN to the targeted endosomal Toll-like receptor 9 (TLR9) to continuously stimulate the secretion of proinflammatory cytokines and the maturation of dendritic cells, thereby resulting in the activation and infiltration of T lymphocytes. As a result, PC@GCpD(Gd) achieved robust inhibition efficiency to almost completely suppress the EMT6 murine mammary cancer model under laser irradiation, implying the superior synergy of combined photoimmunotherapy. Moreover, the in vivo delivery and biodistribution ofPC@GCpD(Gd) could be tracked using the high-quality bimodal magnetic resonance imaging/fluorescence imaging. This study highlighted the potent prospect of hybridPC@GCpD(Gd) nanoassemblies for precise cancer photoimmunotherapy with a cascading effect.