Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents. Issue 3 (1st February 2018) - Humphries, Paul S.
Graphical abstract: Abstract: A series of novel carbazole-containing amides and ureas were synthesized. A structure–activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the desired pharmacokinetic/pharmacodynamic parameters and the results of efficacy studies in db/db mice, compound50 was selected for further profiling.