Potential application of zerumbone in the prevention and therapy of chronic human diseases. (February 2019)

• Record Type: Journal Article
• Authors: Singh, Yogendra Prakash; Girisa, Sosmitha; Banik, Kishore; Ghosh, Sharad; Swathi, Pantheerayil; Deka, Manab; Padmavathi, Ganesan; Kotoky, Jibon; Sethi, Gautam; Fan, Lu; Mao, Xinliang; Halim, Clarissa Esmeralda; Arfuso, Frank; Kunnumakkara, Ajaikumar B.
• Is Part Of: Journal of functional foods. Volume 53(2019)
• Page Start: 248
• Page End: 258
• Publication Date: 2019-02
• Subjects: Zerumbone -- Zingiber zerumbet -- Chronic diseases -- Inflammation -- NF-κB -- PI3K/mTOR; OSCC Oral squamous cell carcinoma -- GSH glutathione -- MDA Malondialdehyde -- PGE2 prostaglandin E2 -- CCI chronic constriction injury -- LDL low-density lipoprotein -- oxLDL oxidized LDL -- ZPD Zerumbone pendant derivative -- FOXO1 Forkhead box protein O1 -- PGC1α peroxisome proliferator-activated receptor gamma coactivator 1-alpha -- SREBPs sterol response element binding protein -- PPARα peroxisome proliferator-activated receptor alpha -- HFS high-fat diet -- TRP transient receptor potential -- TRPV1 transient receptor potential cation channel subfamily V member 1 -- TRPA1 transient receptor potential ankyrin A1 channel -- iNOS inducible nitric oxide synthase -- COX-2 cyclooxygenase -- MTTP microsomal triglyceride transfer protein -- Bcl-xL B-cell lymphoma-extra-large -- Lck lymphocyte-specific protein tyrosine kinase -- LDL-r low density lipoprotein-receptor -- PARP poly ADP ribose polymerase -- Bcl-2 B-cell lymphoma 2 -- JAK2 Janus kinase 2 -- STAT3 signal transducer and activator of transcription 3 -- MAPK mitogen-activated protein kinase -- ERK extracellular signal-regulated kinase -- NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells -- IL-1β interleukin-1beta -- TGF-β1 transforming growth factor-beta -- FN induced fibronectin; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.12.020
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Zerumbone can exhibit potent chemopreventive and therapeutic effects against various chronic diseases. It can alter the expression of various signaling molecules involved in disease progression. Zerumbone has been reported to be relatively non-toxic in analyzed disease models so far. Abstract: Several active compounds from 'Mother Nature' have been found to be tailor-made therapeutics for the better management of numerous chronic ailments, with fewer adverse side effects. Zerumbone is one such molecule isolated from the rhizomes of Zingiber zerumbet (L.) Smith, a Zingiberaceae plant with significant medicinal values that has been used traditionally for treating stomach ache, ulcers, diabetes, leprosy, asthma, and skin diseases. Zerumbone has been found to be the most important active compound of Z. zerumbet, contributing to its anti-inflammatory, anti-microbial, anti-hypersensitivity, chemopreventive and chemotherapeutic activities. It has been established as a multi-targeted agent with potential to treat chronic diseases such as osteoarthritis, obesity, diabetes, diabetic nephropathy, diabetic retinopathy, chronic gastritis, neuropathic pain, atherosclerosis, inflammation and cancer through modulation of various cellular signaling cascades and antigen presentation pathways. Therefore, the present study focuses on zerumbone, its sources and biological activities against various chronic diseases by summarizing the literature available.