Effects of equivalent medium-chain diacylglycerol or long-chain triacylglycerol oil intake via muffins on postprandial triglycerides and plasma fatty acids levels. (February 2019) - Lee, Ayoung
Graphical abstract: Highlights: MCDG oil is advantageous to control postprandial lipid response in healthy adults. Compared to LCT, postprandial serum/chylomicron-TG decreased after MCDG intake. In addition to TGs, postprandial plasma fatty acids also reduced after MCDG intake. Metabolic characteristics of MCDG in the digestive tract may exhibit these changes. Abstract: We assessed the effects of medium-chain diacylglycerol (MCDG) oil on postprandial triglycerides (TGs) and plasma fatty acids through a clinical trial (NCT03415568;clinicaltrials.gov ). Meal tolerance tests using muffins containing 15 g of MCDG oil (MCDG muffins, test) or long-chain triacylglycerol (LCT) oil (LCT muffins, control) were conducted. Blood samples were collected under fasting conditions (0 h) and at 2, 3, 4, and 6 h after muffin ingestion. Compared to LCT muffin consumption, serum TG and chylomicron-TG levels were significantly lower at 3 and 4 h and at 4 h, respectively. The area under the curve for serum TG and chylomicron-TG decreased approximately 13% after MCDG muffin consumption although the decreases were not statistically significant (borderline significance: TG AUC; p = 0.052, Chylomicron-TG; p = 0.081). Postprandial fatty acid levels (palmitic acid, stearic acid, and linoleic acid) were also decreased after MCDG muffin intake. These results suggest potential benefits of MCDG oil in postprandial lipid control.