Phyllodulcin, a natural functional sweetener, improves diabetic metabolic changes by regulating hepatic lipogenesis, inflammation, oxidative stress, fibrosis, and gluconeogenesis in db/db mice. (March 2018)

• Record Type: Journal Article
• Authors: Kim, Eunju; Shin, Jae-Ho; Seok, Pu Reum; Kim, Min-Soo; Yoo, Sang-Ho; Kim, Yuri
• Is Part Of: Journal of functional foods. Volume 42(2018)
• Page Start: 1
• Page End: 11
• Publication Date: 2018-03
• Subjects: ACC acetyl-CoA carboxylase -- aP2 adipocyte protein 2 -- α-SMA α-smooth muscle actin -- Collagen type 1 collagen -- ERK extracellular signal–regulated kinases -- FAS fatty acid synthase -- G6Pase glucose-6-phosphatase -- GAPDH glyceraldehyde-3-phosphate dehydrogenase -- GK glucokinase -- GOT glutamic oxaloacetic transaminase -- GPT glutamic pyruvate transaminase -- GPx Glutathione peroxidase -- HbA1c Glycated hemoglobin -- HO-1 Heme oxygenase-1 -- IFN-γ interferon γ -- IL-1β interleukin-1β -- iNOS Inducible Nitric Oxide Synthase -- JNK c-Jun N-terminal kinases -- MAPK mitogen-activated protein kinase -- MMP2 matrix metallopeptidase 2 -- NAFLD non-alcoholic fatty liver disease -- NASH non-alcoholic steatohepatitis -- NO nitric oxide -- OGTT oral glucose tolerance test -- p38 p38 mitogen-activated protein kinases -- PEPCK phosphoenolpyruvate carboxykinase -- PPARγ peroxisome proliferator activated receptor γ -- ROS reactive oxygen species -- SOD2 Superoxide Dismutase 2 -- SREBP-1C sterol regulatory element-binding protein-1C -- T2D type 2 diabetes -- TNFα tumor necrosis factor α; Phyllodulcin -- Natural sweetener -- Db/db mice -- Hepatic lipogenesis -- Inflammation -- Gluconeogenesis; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.12.038
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Phyllodulcin improved diabetic metabolic changes in db/db/ mice. Phyllodulcin lowered water and food intake. Phyllodulcin suppressed the levels of fasting blood glucose and HbA1c. Phyllodulcin improved hepatic lipogenesis. Phyllodulcin suppressed inflammation and oxidative stress. Phyllodulcin inhibited hepatic fibrosis and regulated liver glucose homeostasis. Abstract: Phyllodulcin, an isocoumarin derivatives and well-known natural sweetener derived from Hydrangea macrophylla var, was evaluated for its roles in diabetes-related metabolic and genetic changes by regulating glucose homeostasis in the liver. C57BL/KsJ-db/db mice received 20 mg/kg body weight (b.w.) stevioside (SVS 20), 10 mg/kg b.w. phyllodulcin (P 10), or 20 mg/kg b.w. phyllodulcin (P 20) for four weeks. Water and food intake were significantly lower in the phyllodulcin supplemented group compared with the diabetic group. Phyllodulcin supplementation suppressed the levels of fasting blood glucose, HbA1c, and plasma and hepatic triglyceride level. Phyllodulcin improved hepatic lipogenesis, while also suppressing inflammation and oxidative stress. Phyllodulcin inhibited hepatic fibrosis and regulated liver glucose homeostasis. Thus, these results indicate the potential of phyllodulcin to serve as a therapeutic agent to improve global hepatic function and metabolic abnormalities of diabetic conditions and the necessity to be better explored.