Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits. (March 2018)

• Record Type: Journal Article
• Authors: Liu, Zhigang; Liu, Xiaoning; Luo, Shunyi; Chu, Chuanqi; Wu, Dandan; Liu, Runhua; Wang, Lei; Wang, Jiamin; Liu, Xuebo
• Is Part Of: Journal of functional foods. Volume 42(2018)
• Page Start: 237
• Page End: 247
• Publication Date: 2018-03
• Subjects: CUMS chronic unpredictable mild stress -- SLE sesame cake extract -- NE norepinephrine -- 5-HT serotonin -- NF-κB Nuclear factor kappaB -- PSDs postsynaptic densities -- MAO monoamine oxidase -- HPA hypothalamus-pituitary-adrenal -- CAT catalase -- MDA malondialdehyde -- GSH glutathione -- BDNF brain derived neurotrophic factor; Sesame cake extract -- Chronic unpredictable stress -- Antidepressant -- Serotonin -- Oxidative stress -- Postsynaptic densities; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.01.005
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: SLE and sesamol attenuated depressive-like behaviors in a CUMS-induced mice model. SLE and sesamol suppressed stress-induced working and spatial memory loss. SLE and sesamol inhibited stress-induced unbalance of redox status in mice brain. SLE and sesamol treatment restored stress-trigged size of postsynaptic densities decreasing. Supplementation of SLE and sesamol enhanced expression of BDNF and PSD-95 in depressed mice brain. Abstract: Depression is a worldwide severe psychiatric disease associated with cognitive impairments. The aims of the present study are to investigate the preventive effects of alcoholic extract of sesame ( Sesamum indicum L.) cake (SLE) and sesamol in a chronic unpredictable mild stress (CUMS)-induced mouse model. Oral administration of SLE (600 mg/kg/day) and sesamol (10 mg/kg/day) significantly restored CUMS-induced mice antidepressant-like behaviors, anhedonia, and anxiety. Importantly, supplementation of SLE and sesamol inhibited oxidative stress and improved serotonin levels in depressed mice brain. Moreover, SLE and sesamol treatment significantly prevented CUMS-induced memory loss in Y-maze and water-maze tests, which was consistent with enhanced the size of postsynaptic densities and postsynaptic density protein 95 (PSD-95) expression in mice hippocampus. These results illustrated that SLE and sesamol markedly improved CUMS-induced depression and memory loss, and provided novel insights into the mechanisms of sesamol and sesame crude extract on the regulation CUMS-induced depression and cognitive impairments.