Extruded sorghum flour (Sorghum bicolor L.) modulate adiposity and inflammation in high fat diet-induced obese rats. (March 2018)

• Record Type: Journal Article
• Authors: Arbex, Priscila Marques; Moreira, Maria Eliza de Castro; Toledo, Renata Celi Lopes; de Morais Cardoso, Leandro; Pinheiro-Sant'ana, Helena Maria; Benjamin, Laércio dos Anjos; Licursi, Leandro; Carvalho, Carlos Wanderlei Piler; Queiroz, Valeria Aparecida Vieira; Martino, Hércia Stampini Duarte
• Is Part Of: Journal of functional foods. Volume 42(2018)
• Page Start: 346
• Page End: 355
• Publication Date: 2018-03
• Subjects: Adipogenic genes -- IL-10 -- Obesity -- Phenolic compounds -- TNF-α; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.01.010
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Sorghum may be used as a potential functional food for managing obesity. Extruded sorghum flour presented potent anti-obesity activities. Sorghum regulated lipogenic genes such as FAS, PPAR-γ, and LPL. Abstract: The aim was to determine the effect of extruded sorghum flour (ESF) on the adiposity and inflammation modulation in obese Wistar rats. Four experimental groups: normal control (AIN-93), obese control (HFD) and two tested groups (replacing 50% of cellulose and 100% of cornstarch by ESF in the HFD - HFDS50; and replacing 100% of cellulose and 100% of cornstarch by ESF in the HFD - HFDS100) were used. The luteolinidin and 5-methoxy-luteliolinidin were the main deoxyanthocianidins identified in ESF. The Lee index, percentage of adiposity, fatty acid synthase gene expression, TNF-α, blood levels of glucose and the adipocyte hypertrophy were lower in the groups treated with ESF when compared to HFD. The groups treated with ESF up-regulated the lipoprotein lipase, peroxisome proliferator activated receptor-γ gene expression and IL-10. ESF has potential as a functional food since it reduced the metabolic risk of obesity associated with adiposity and inflammation.