Immunosuppression-induced alterations in fish gut microbiota may increase the susceptibility to pathogens. Issue 88 (May 2019)

• Record Type: Journal Article
• Authors: Qi, Xiao-Zhou; Tu, Xiao; Zha, Ji-Wei; Huang, Ai-Guo; Wang, Gao-Xue; Ling, Fei
• Is Part Of: Fish & shellfish immunology. Issue 88(2019)
• Page Start: 540
• Page End: 545
• Publication Date: 2019-05
• Subjects: Crucian carp -- Dexamethasone -- Gut microbiota -- Immune; Fishes -- Immunology -- Periodicals; Shellfish -- Immunology -- Periodicals; Poissons -- Immunologie -- Périodiques; Crustacés -- Immunologie -- Périodiques; 571.9617
• DOI: 10.1016/j.fsi.2019.03.035
• Languages: English
• ISSNs: 1050-4648

Abstract

Abstract: Intestinal bacteria play an important role in the health and provide a variety of beneficial effects to host. Immunosuppressant can reduce the immunity of host and increase the susceptibility to pathogens. But it is not clear whether the increased susceptibility caused by immunosuppressant is related to changes of gut microbiota. In this study, we used crucian carp administrated with dexamethasone to explore the effects of immunosuppressants on gut microbial communities and further evaluate the potential association between changes in gut microbiota and susceptibility to pathogens. The results of MANOVA based on the top 10 PCoA axis scores from unweighed/weighted UniFrac distances showed that administration of dexamethasone ( P = 0.021) and the administration time ( P = 0.027) had a significant impact on the gut microbial composition, regardless of pathogens infection status ( P = 0.35). After administration with dexamethasone, the fish had higher abundance of Cetobacterium and lower abundance of Bacillus and Lactococcus, and the abundance of genus Bacillus, Pseudomonas and Lactococcus decreased along with prolong administration time of dexamethasone. The results may help us understand the correlation between the host susceptibility to pathogenic bacteria and gut microbial community shift, and extend our knowledge regarding the role of gut microbiota in keeping the balance between pathogenic and symbiotic bacteria. Highlights: Administration of dexamethasone had a significant impact on the gut microbial composition. Fish had higher level of Cetobacterium and lower Bacillus and Lactococcus genus after injected with dexamethasone. The level of genus Bacillus, Pseudomonas and Lactococcus decreased along with prolong administration time of dexamethasone.