Diagnostic accuracy of dynamic contrast‐enhanced perfusion MRI in stratifying gliomas: A systematic review and meta‐analysis. (7th August 2019)

• Record Type: Journal Article
• Authors: Okuchi, Sachi; Rojas‐Garcia, Antonio; Ulyte, Agne; Lopez, Ingeborg; Ušinskienė, Jurgita; Lewis, Martin; Hassanein, Sara M; Sanverdi, Eser; Golay, Xavier; Thust, Stefanie; Panovska‐Griffiths, Jasmina; Bisdas, Sotirios
• Is Part Of: Cancer medicine. Volume 8:Number 12(2019:Sep.)
• Page Start: 5564
• Page End: 5573
• Publication Date: 2019-08-07
• Subjects: dynamic contrast‐enhanced MRI -- gliomas -- lymphoma -- meta‐analysis -- perfusion; 616.994005
• DOI: 10.1002/cam4.2369
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Background: T1‐weighted dynamic contrast‐enhanced (DCE) perfusion magnetic resonance imaging (MRI) has been broadly utilized in the evaluation of brain tumors. We aimed at assessing the diagnostic accuracy of DCE‐MRI in discriminating between low‐grade gliomas (LGGs) and high‐grade gliomas (HGGs), between tumor recurrence and treatment‐related changes, and between primary central nervous system lymphomas (PCNSLs) and HGGs. Methods: We performed this study based on the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis of Diagnostic Test Accuracy Studies criteria. We systematically surveyed studies evaluating the diagnostic accuracy of DCE‐MRI for the aforementioned entities. Meta‐analysis was conducted with the use of a random effects model. Results: Twenty‐seven studies were included after screening of 2945 possible entries. We categorized the eligible studies into three groups: those utilizing DCE‐MRI to differentiate between HGGs and LGGs (14 studies, 546 patients), between recurrence and treatment‐related changes (9 studies, 298 patients) and between PCNSLs and HGGs (5 studies, 224 patients). The pooled sensitivity, specificity, and area under the curve for differentiating HGGs from LGGs were 0.93, 0.90, and 0.96, for differentiating tumor relapse from treatment‐related changes were 0.88, 0.86, and 0.89, and for differentiating PCNSLs from HGGs were 0.78, 0.81, and 0.86, respectively. Conclusions: Dynamic contrast‐enhanced‐Magnetic resonance imaging is a promising noninvasive imaging method that has moderate or high accuracy in stratifying gliomas. DCE‐MRI shows high diagnostic accuracy in discriminating between HGGs and their low‐grade counterparts, and moderate diagnostic accuracy in discriminating recurrent lesions and treatment‐related changes as well as PCNSLs and HGGs. Abstract : Dynamic contrast‐enhanced‐Magnetic resonance imaging has high diagnostic accuracy in grading gliomas and moderate accuracy in surveillance of high‐grade gliomas and differentiation from primary central nervous system lymphomas. DCE‐MRI is a promising noninvasive imaging technique in diagnosing different types of brain tumors.