Nickel‐Catalyzed Asymmetric Reductive Diarylation of Vinylarenes. (11th February 2019)

• Record Type: Journal Article
• Authors: Anthony, David; Lin, Qiao; Baudet, Judith; Diao, Tianning
• Is Part Of: Angewandte Chemie. Volume 131:Number 10(2019)
• Page Start: 3230
• Page End: 3234
• Publication Date: 2019-02-11
• Subjects: Alkene -- Arylbromide -- Asymmetrische Katalyse -- Diarylierungen -- Nickel; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201900228
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: A nickel‐catalyzed asymmetric diarylation reaction of vinylarenes enables the preparation of chiral α, α, β‐triarylated ethane scaffolds, which exist in a number of biologically active molecules. The use of reducing conditions with aryl bromides as coupling partners obviates the need for stoichiometric organometallic reagents and tolerates a broad range of functional groups. The application of an N ‐oxyl radical as a ligand to a nickel catalyst represents a novel approach to facilitate nickel‐catalyzed cross‐coupling reactions.