1, 8‐Naphthalimide: A Potent DNA Intercalator and Target for Cancer Therapy. Issue 10 (4th April 2017)

• Record Type: Journal Article
• Authors: Tandon, Runjhun; Luxami, Vijay; Kaur, Harsovin; Tandon, Nitin; Paul, Kamaldeep
• Is Part Of: Chemical record. Volume 17:Issue 10(2017)
• Page Start: 956
• Page End: 993
• Publication Date: 2017-04-04
• Subjects: Naphthalimide -- DNA Intercalation -- Bis-naphthalimide -- Metal complexes -- Hybrids; Chemistry -- Periodicals; 540
• DOI: 10.1002/tcr.201600134
• Languages: English
• ISSNs: 1527-8999

Abstract

Abstract: The poor pharmacokinetics, side effects and particularly the rapid emergence of drug resistance compromise the efficiency of clinically used anticancer drugs. Therefore, the discovery of novel and effective drugs is still an extremely primary mission. Naphthalimide family is one of the highly active anticancer drug based upon effective intercalator with DNA. In this article, we review the discovery and development of 1, 8‐naphthalimide moiety, and, especially, pay much attention to the structural modifications and structure activity relationships. The review demonstrates how modulation of the moiety affecting naphthalimide compound for DNA binding that is achieved to afford a profile of antitumor activity. The DNA binding of imide and ring substitution at naphthalimide, bisnaphthalimide, naphthalimide‐metal complexes is achieved by molecular recognition through intercalation mode. Thus, this synthetic/natural small molecule can act as a drug when activation or inhibition of DNA function, is required to cure or control the cancer disease. The present study is a review of the advances in 1, 8‐naphthalimide‐related research, with a focus on how such derivatives are intercalated into DNA for their anticancer activities. Abstract : The development of functional 1, 8‐naphthalimide derivatives as DNA intercalation and anticancer agents is a fast growing area. This review gives an overwiew of the many discoveries and the progression of the use of 1, 8‐naphthalimides agents and their applications to date; focusing mainly on imide and ring substitution of naphthalimide and their conjugation, metal complexes with naphthalimide and bis‐naphthalimide based structures. The rich photophysical properties of 1, 8‐naphthalimides make them prime candidates as the changes in spectroscopic properties such as absorption and fluorescence can all be used to monitor their binding.