Preparation of magnetic mesoporous silica nanoparticles as a multifunctional platform for potential drug delivery and hyperthermia. Issue 1 (1st December 2016)

• Record Type: Journal Article
• Authors: Yu, Xia; Zhu, Yufang
• Is Part Of: Science and technology of advanced materials. Volume 17:Issue 1(2016)
• Page Start: 229
• Page End: 238
• Publication Date: 2016-12-01
• Subjects: Mesoporous nanoparticles -- drug delivery -- magnetic hyperthermia -- multifunctionality; 30 Bio-inspired and biomedical materials -- 102 Porous/Nanoporous/Nanostructured materials -- 211 Scaffold/Tissue engineering/Drug delivery; Materials -- Technological innovations -- Periodicals; 620.112
• DOI: 10.1080/14686996.2016.1178055
• Languages: English
• ISSNs: 1468-6996

Abstract

Abstract: We report the preparation of magnetic mesoporous silica (MMS) nanoparticles with the potential multifunctionality of drug delivery and magnetic hyperthermia. Carbon-encapsulated magnetic colloidal nanoparticles (MCN@C) were used to coat mesoporous silica shells for the formation of the core-shell structured MMS nanoparticles (MCN@C/mSiO2 ), and the rattle-type structured MMS nanoparticles (MCN/mSiO2 ) were obtained after the removal of the carbon layers from MCN@C/mSiO2 nanoparticles. The morphology, structure, magnetic hyperthermia ability, drug release behavior, in vitro cytotoxicity and cellular uptake of MMS nanoparticles were investigated. The results revealed that the MCN@C/mSiO2 and MCN/mSiO2 nanoparticles had spherical morphology and average particle sizes of 390 and 320 nm, respectively. The MCN@C/mSiO2 nanoparticles exhibited higher magnetic hyperthermia ability compared to the MCN/mSiO2 nanoparticles, but the MCN/mSiO2 nanoparticles had higher drug loading capacity. Both MCN@C/mSiO2 and MCN/mSiO2 nanoparticles had similar drug release behavior with pH-controlled release and temperature-accelerated release. Furthermore, the MCN@C/mSiO2 and MCN/mSiO2 nanoparticles showed low cytotoxicity and could be internalized into HeLa cells. Therefore, the MCN@C/mSiO2 and MCN/mSiO2 nanoparticles would be promising for the combination of drug delivery and magnetic hyperthermia treatment in cancer therapy. Abstract :