Phase-Contrast Magnetic Resonance Quantification of Aortic Regurgitation in Patients With Turbulent Aortic Flow. Issue 2 (March 2019)

• Record Type: Journal Article
• Authors: Lee, Elizabeth; Richards, Blair; Lu, Jimmy C.; Mahani, Maryam Ghadimi; Dorfman, Adam L.; Balasubramanian, Sowmya; Agarwal, Prachi P.
• Is Part Of: Journal of computer assisted tomography. Volume 43:Issue 2(2019)
• Publication Date: 2019-03
• Subjects: phase-contrast MR -- aortic regurgitation -- aortic stenosis -- aortic dilation; Tomography -- Periodicals; Tomography -- Periodicals; Tomography; Periodicals; 616.0757
• DOI: 10.1097/RCT.0000000000000819
• Languages: English
• ISSNs: 0363-8715

Abstract

Abstract : Objective: This study aimed to assess variability in measurements and accurately quantify aortic regurgitation in patients with coexisting turbulent aortic flow using phase-contrast magnetic resonance. Methods: All patients (n = 21) underwent phase-contrast magnetic resonance at 2 or more sites: ascending aorta, sinuses of Valsalva, and left ventricular outflow tract. The net flow/minute (NF), forward flow/minute (FF), regurgitant flow/minute (RF), and regurgitant fraction (RF%) were compared with the sum of superior vena cava and descending aortic flow/minute, left ventricular cardiac output, difference between the 2, and percentage difference, respectively. Results: The NF, FF, and RF were significantly different between each site. The combination of FF in the left ventricular outflow tract and NF from the superior vena cava + descending aorta provided the best reliability of RF and regurgitant fraction (intraclass correlation coefficients, 0.881 [95% confidence interval, 0.882–0.878] and 0.838 [95% confidence interval, 0.837–0.838]). Conclusion: Combining flow measurements from more than 1 site provides the most accurate quantification of aortic regurgitation in patients with turbulent aortic flow.