Screening of ligands for redox-active europium using magnetic resonance imaging. Issue 19 (15th October 2018)

• Record Type: Journal Article
• Authors: Corbin, Brooke A.; Basal, Lina A.; White, Susan A.; Shen, Yimin; Haacke, E. Mark; Fishbein, Kenneth W.; Allen, Matthew J.
• Is Part Of: Bioorganic & medicinal chemistry. Volume 26:Issue 19(2018)
• Page Start: 5274
• Page End: 5279
• Publication Date: 2018-10-15
• Subjects: Coordination chemistry -- Europium -- Magnetic resonance imaging -- Screening; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2018.04.001
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: We report a screening procedure to predict ligand coordination to Eu II and Eu III using magnetic resonance imaging in which bright images indicate complexation and dark images indicate no complexation. Here, paramagnetic Gd III is used as a surrogate for Eu III in the screening procedure to enable detection with magnetic resonance imaging. The screening procedure was tested using a set of eight ligands with known coordination to Eu II and Eu III, and results were found to be consistent with expected binding. Validation of the screening procedure with known coordination chemistry enables use with new ligands in the future.