Targeted Protein Delivery: Supramolecular Toxin Complexes for Targeted Pharmacological Modulation of Polymorphonuclear Leukocyte Functions (Adv. Healthcare Mater. 17/2019). Issue 17 (5th September 2019)

• Record Type: Journal Article
• Authors: Heck, Astrid Johanna; Ostertag, Theresa; Schnell, Leonie; Fischer, Stephan; Agrawalla, Bikram Keshari; Winterwerber, Pia; Wirsching, Eva; Fauler, Michael; Frick, Manfred; Kuan, Seah Ling; Weil, Tanja; Barth, Holger
• Is Part Of: Advanced healthcare materials. Volume 8:Issue 17(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-09-05
• Subjects: C3 Rho inhibitor -- polymorphonuclear leukocytes (PMNs) -- supramolecular toxin complex -- targeted protein delivery; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201970072
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Excessive recruitment of polymorphonuclear neutrophils (PMNs) into injured tissues after traumatic injuries can be highly detrimental to patients and remains a significant source of morbidity and mortality. In article number1900665 by Seah Ling Kuan, Tanja Weil, Holger Barth, and co‐workers, the authors develop supramolecular protein complexes for pharmacological modulation of PMNs. In this way, a novel therapeutic approach is formulated by fusing PMN‐binding peptides to a Rho‐inhibiting enzyme on a supramolecular platform.