Successful endovascular recanalization of massive cerebral venous sinus thrombosis in a patient with tuberous sclerosis and protein S deficiency: a case report. Issue 7 (12th July 2019)

• Record Type: Journal Article
• Authors: Nishiyama, Yasuhiro; Ueda, Masayuki; Muraga, Kanako; Ota, Takahiro; Horikawa, Hiroshi; Kimura, Kazumi
• Is Part Of: Oxford medical case reports. Volume 2019:Issue 7(2019)
• Publication Date: 2019-07-12
• Subjects: Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1093/omcr/omz060
• Languages: English
• ISSNs: 2053-8855

Abstract

Abstract: Here, we report the case of a 27-year-old woman with tuberous sclerosis complex who underwent successful endovascular intervention for cerebral venous thrombosis at the superior sagittal sinus. She had protein S deficiency and a long-term history of anemia caused by menorrhagia from uterine fibroids, possibly leading to a hypercoagulable state. Cerebral venous sinus thrombosis accounts for ~0.5–1% of all strokes. Several cases of venous thrombosis in patients with tuberous sclerosis complex and protein S or protein C deficiency have been reported, but further studies are needed to identify whether an association of this rare combination may be explained.