Genetic Diversity of Persian Arabian Horses and Their Relationship to Other Native Iranian Horse Breeds. (27th December 2018)
- Record Type:
- Journal Article
- Title:
- Genetic Diversity of Persian Arabian Horses and Their Relationship to Other Native Iranian Horse Breeds. (27th December 2018)
- Main Title:
- Genetic Diversity of Persian Arabian Horses and Their Relationship to Other Native Iranian Horse Breeds
- Authors:
- Sadeghi, Raheleh
Moradi-Shahrbabak, Mohammad
Miraei Ashtiani, Seyed Reza
Schlamp, Florencia
Cosgrove, Elissa J
Antczak, Doug F - Abstract:
- Abstract: The principal aims of this study were to explore genetic diversity and genome-wide selection signatures in Persian Arabian horses and to determine genetic relationship of Persian Arabians with other Iranian horse breeds. We evaluated 71 horses from 8 matrilineal strains tracing to 47 mares from the mid to late 19th century, using the equine 670k single nucleotide polymorphism (SNP) BeadChip. Mean observed and expected heterozygosity were (0.43) and (0.45), respectively, average inbreeding measures (inbreeding estimates based on runs of homozygosity and pedigree information) were low, indicating high genetic diversity in Persian Arabian horses. Analysis of population genetic structure using STRUCTURE and principal component analysis suggested that Persian Arabian horses can be divided into 3 groups, however the groups do not match traditional matrilineal strains. In total, 15 genomic regions were identified by at least 2 of the 3 implemented methods, Tajima's D, H, and H12, as potentially under selection in Persian Arabian horses. Most of these peaks were found on chromosome 9, overlapping with QTLs previously associated with horse temperament. Biological function analysis of identified candidate genes highlighted enrichment of GO term "response to lipopolysaccharide" and KEGG pathway "chemokine-mediated signaling pathway, " which are associated with immune responses and may have been targets of selection in Persian Arabian horses. Independent analyses of SNP dataAbstract: The principal aims of this study were to explore genetic diversity and genome-wide selection signatures in Persian Arabian horses and to determine genetic relationship of Persian Arabians with other Iranian horse breeds. We evaluated 71 horses from 8 matrilineal strains tracing to 47 mares from the mid to late 19th century, using the equine 670k single nucleotide polymorphism (SNP) BeadChip. Mean observed and expected heterozygosity were (0.43) and (0.45), respectively, average inbreeding measures (inbreeding estimates based on runs of homozygosity and pedigree information) were low, indicating high genetic diversity in Persian Arabian horses. Analysis of population genetic structure using STRUCTURE and principal component analysis suggested that Persian Arabian horses can be divided into 3 groups, however the groups do not match traditional matrilineal strains. In total, 15 genomic regions were identified by at least 2 of the 3 implemented methods, Tajima's D, H, and H12, as potentially under selection in Persian Arabian horses. Most of these peaks were found on chromosome 9, overlapping with QTLs previously associated with horse temperament. Biological function analysis of identified candidate genes highlighted enrichment of GO term "response to lipopolysaccharide" and KEGG pathway "chemokine-mediated signaling pathway, " which are associated with immune responses and may have been targets of selection in Persian Arabian horses. Independent analyses of SNP data from 30 horses of 4 other Iranian breeds suggested distinct population structure between Persian Arabian, and Turkemen and Caspian horse breeds. Overall, the results of this study suggest a rich genetic diversity in the Persian Arabian horses and a clear genetic differentiation with Turkemen and Caspian breeds. … (more)
- Is Part Of:
- Journal of heredity. Volume 110:Number 2(2019)
- Journal:
- Journal of heredity
- Issue:
- Volume 110:Number 2(2019)
- Issue Display:
- Volume 110, Issue 2 (2019)
- Year:
- 2019
- Volume:
- 110
- Issue:
- 2
- Issue Sort Value:
- 2019-0110-0002-0000
- Page Start:
- 173
- Page End:
- 182
- Publication Date:
- 2018-12-27
- Subjects:
- genetic diversity -- Persian Arabian horse -- ROH -- selective sweeps -- SNP -- structure
Breeding -- Periodicals
Plant breeding -- Periodicals
Heredity -- Periodicals
576.5 - Journal URLs:
- http://jhered.oxfordjournals.org/ ↗
http://ukcatalogue.oup.com/ ↗ - DOI:
- 10.1093/jhered/esy061 ↗
- Languages:
- English
- ISSNs:
- 0022-1503
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4998.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 11744.xml