Silica Gel‐mediated Synthesis of β‐Enamino Esters and its Application for the Synthesis of Indeno 4‐Hydroxypyridin‐2(1H)‐Ones. (30th January 2019)

• Record Type: Journal Article
• Authors: Kim, Soong‐Hyun; Bae, Seri; Ko, Eun Bi; Park, Ga Young; Lee, Eunhye; Hwang, Hee Jong; Im, Chun Young; Song, Minsoo
• Is Part Of: Bulletin of the Korean Chemical Society. Volume 40:Number 3(2019)
• Page Start: 262
• Page End: 269
• Publication Date: 2019-01-30
• Subjects: SiO2‐based condensation -- β‐keto ester -- β‐enamino ester -- 4‐hydroxypyridine‐2(1H)‐one; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/bkcs.11676
• Languages: English
• ISSNs: 0253-2964

Abstract

Abstract : The full scope of SiO2 ‐based condensation of aliphatic or aromatic amines and β‐keto esters to give β‐enamino esters was examined. Functionalized linear β‐enamino esters were easily obtained from SiO2 ‐based condensation of β‐keto esters and amines only after simple filtration. It was also demonstrated that cyclic β‐enamino esters with 99% purity can be prepared in a practically large scale (60 g) without using silica gel column chromatography. The utility of the present method was fortified by the preparation of pharmaceutically useful indeno‐4‐hydroxypyridin‐2(1H)‐one analogue11 . Abstract :