Towards clinical application of non-invasive imaging to detect bacterial infections. Issue 1 (31st December 2018)

• Record Type: Journal Article
• Authors: Ohlsen, Knut; Hertlein, Tobias
• Is Part Of: Virulence. Volume 9:Issue 1(2018)
• Page Start: 943
• Page End: 945
• Publication Date: 2018-12-31
• Subjects: fluorescence imaging -- imaging probes -- in vivo imaging -- infection imaging -- magnetic resonance imaging -- molecular imaging -- PET imaging -- Staphylococcus aureus infections; Virulence (Microbiology) -- Periodicals; Bacterial diseases -- Periodicals; Molecular microbiology -- Periodicals; 579.05
• DOI: 10.1080/21505594.2018.1425072
• Languages: English
• ISSNs: 2150-5608

Abstract

ABSTRACT: In vivo imaging technologies offer a great potential for the diagnosis of difficult-to-treat bacterial infections. A major limitation of conventional imaging modalities is the lack of specificity to distinguish the site of bacterial infection from sterile inflammation. Targeted approaches like antibiotics linked to imaging tracers for detection of various bacterial pathogens or species-specific antibodies combined with anatomical imaging modalities are currently being evaluated to overcome this problem. Considering the recent progress in optical and targeted imaging that may accelerate preclinical development programs, clinical implementation of in vivo imaging modalities to detect bacterial infection foci becomes realistic in the future.