Human Papillomavirus (HPV)-associated Lymphoepithelioma-like Carcinoma of the Vagina and Anal Canal: A Rare Variant of Squamous Cell Carcinoma. (March 2019)

• Record Type: Journal Article
• Authors: Scott, Kerry; Trainor, James; McVeigh, Gerard; Jamison, Jackie; Loughrey, Maurice B.; Kelly, Paul J.; McCluggage, W. Glenn
• Is Part Of: International journal of gynecological pathology. Volume 38:Number 2(2019)
• Publication Date: 2019-03
• Subjects: Vagina -- Anal canal -- Lymphoepithelioma-like carcinoma (LELC) -- Immunohistochemistry -- Human papillomavirus (HPV); Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000483
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : Lymphoepithelioma-like carcinoma (LELC) is an uncommon variant of squamous cell carcinoma, which is histologically identical to lymphoepithelial carcinoma of the nasopharynx. LELCs have been reported at a variety of sites, including the stomach, salivary gland, thymus, cervix, endometrium, breast, skin, bladder, and lung. We report 2 LELCs of the vagina and 1 of the anal canal, the first report of LELC at the latter site. All 3 neoplasms were diffusely positive with p16 (block-type immunoreactivity) and the anal canal lesion contained high-risk human papillomavirus type 16; the 2 vaginal neoplasms underwent human papillomavirus testing but were unsuitable for analysis. All cases were Epstein-Barr virus negative. In reporting these cases, we highlight the potential for misdiagnosis and suggest an association with human papillomavirus infection similar to LELCs in the uterine cervix.