Neoplasia in Three Aye-Ayes (Daubentonia madagascariensis). (February 2018)

• Record Type: Journal Article
• Authors: Rodriguez Barbon, A.; Cowen, R.; Knott, C.; Hughes, K.; Allinson, K.; Williams, C.V.; Routh, A.
• Is Part Of: Journal of comparative pathology. Volume 159(2018)
• Page Start: 16
• Page End: 20
• Publication Date: 2018-02
• Subjects: aye-aye -- Daubentonia madagascariensis -- immunohistochemistry -- neoplasia; Veterinary pathology -- Periodicals; Veterinary therapeutics -- Periodicals; Pathology, Comparative -- Periodicals; Therapeutics -- Periodicals; Pathology, Veterinary -- Periodicals; 636.089607
• DOI: 10.1016/j.jcpa.2017.12.008
• Languages: English
• ISSNs: 0021-9975

Abstract

Summary: Tumours diagnosed in three aged captive aye-ayes ( Daubentonia madagascariensis ), held in two different institutions, are described. A cerebral glioblastoma was diagnosed based on histological and immunohistochemical findings in one of the animals following initial presentation with bilateral mydriasis, absent pupillary reflex, head tilt and ataxia. A second animal was humanely destroyed due to impaired locomotion associated with spondylosis and a post-mortem diagnosis of cholangiocarcinoma was made based on histology with further confirmation with immunohistochemical labelling for cytokeratin 7. A third aye-aye suffering from dental disease was diagnosed with an oral squamous cell carcinoma following an excisional biopsy from a non-healing wound in the lip. Due to progression of the neoplasia the animal was humanely destroyed and post-mortem examination revealed the presence on an additional unilateral phaeochromocytoma.