Interfacial bioconjugation on emulsion droplet for biosensors. Issue 19 (15th October 2018)

• Record Type: Journal Article
• Authors: Zhang, Qifan; Scigliano, Anita; Biver, Tarita; Pucci, Andrea; Swager, Timothy M.
• Is Part Of: Bioorganic & medicinal chemistry. Volume 26:Issue 19(2018)
• Page Start: 5307
• Page End: 5313
• Publication Date: 2018-10-15
• Subjects: Bioconjugation -- Biosensors -- Interfacial functionalization -- Emulsions -- Janus particles; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2018.04.020
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: Interfacial bioconjugation methods are developed for intact liquid emulsion droplets. Complex emulsion droplets having internal hydrocarbon and fluorocarbon immiscible structured phases maintain a dynamic interface for controlled interfacial reactivity. The internal morphological change after binding to biomolecules is readily visualized and detected by light transmission, which provides a platform for the formation of inexpensive and portable bio-sensing assays for enzymes, antibodies, nucleic acids and carbohydrates.